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4888
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2012
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Publié par
Date de parution
05 novembre 2012
Nombre de lectures
3
EAN13
9781455740413
Langue
English
Poids de l'ouvrage
12 Mo
Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options.
- Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located.
- Make confident, effective clinical decisions by consulting the world's most trusted hematology reference.
- Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more.
- Apply all the latest knowledge on regulation of gene expression, transcription splicing, and RNA metabolism; pediatric transfusion therapy; principles of cell-based gene therapy; allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults; hematology in aging; and much more, thanks to 27 brand-new chapters plus sweeping updates throughout.
- Find the information you need quickly and easily thanks to a completely reworked organization that better reflects today’s clinical practice.
- Visualize clinical problems more clearly with new and updated images that reflect the pivotal role of hematopathology in modern practice.
- Benefit from the experience and fresh perspective of new editor Dr. Jeffrey Weitz, Professor of Medicine at McMaster University School of Medicine and Executive Director of the Thrombosis and Atherosclerosis Research Institute in Ontario.
Publié par
Date de parution
05 novembre 2012
Nombre de lectures
3
EAN13
9781455740413
Langue
English
Poids de l'ouvrage
12 Mo
Hematology
Basic Principles and Practice
Sixth Edition
Ronald Hoffman, MD
Albert A. and Vera G. List Professor of Medicine, Tisch Cancer Institute, Department of Medicine, Mount Sinai School of Medicine, New York, New York
Edward J. Benz, Jr., MD
President and Chief Executive Officer, Dana-Farber Cancer Institute, Director and Principal Investigator, Harvard Cancer Center
Richard and Susan Smith Professor of Medicine, Professor of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts
Leslie E. Silberstein, MD
Director, Joint Program in Transfusion Medicine, Children’s Hospital Boston
Director, Center for Human Cell Therapy, Boston, Massachusetts
Helen E. Heslop, MD
Dan L. Duncan Chair, Professor of Medicine and Pediatrics
Director, Adult Stem Cell Transplant Program, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Texas Children’s Hospital, Houston, Texas
Jeffrey I. Weitz, MD
Professor, Division of Hematology and Thromboembolism, Department of Medicine, McMaster University
Director, Juravinski Hospital and Cancer Center, Hamilton, Ontario, Canada
John Anastasi, MD
Associate Professor, Department of Pathology, University of Chicago, Chicago, Illinois
Saunders
Table of Contents
Instructions for online access
Cover image
Title page
Copyright
Dedication
Contributors
Preface
Part I: Molecular and Cellular Basis of Hematology
Chapter 1: Anatomy and Physiology of the Gene
The Genetic View of the Biosphere: the Central Dogma of Molecular Biology
Anatomy and Physiology of Genes
Storage and Transmission of Genetic Information
Expression of Genetic Information Through the Genetic Code and Protein Synthesis
mRNA Metabolism
Gene Regulation
Epigenetic Regulation of Gene Expression
Enhancers, Promoters, and Silencers
Transcription Factors
Regulation of mRNA Splicing, Stability, and Translation (Posttranscriptional Regulation)
Small Interfering RNA and Micro RNA
Additional Structural Features of Genomic DNA
Key Methods for Gene Analysis
Use of Transgenic and Knockout Mice to Define Gene Function
DNA-Based Therapies
Future Directions
Chapter 2: Genomic Approaches to Hematology
Principles of Genomic Approaches
Importance of Sample Acquisition
Analytical Considerations
Next-Generation Sequencing Technology
DNA-Level Characterization
RNA-Level Characterization
Protein-Level Characterization
Metabolite-Level Characterization
Functional Genomics
Pharmacogenomics
Clinical Use of Genomics
Future Directions
Chapter 3: Regulation of Gene Expression, Transcription, Splicing, and Rna Metabolism
How Genes are Organized in DNA
Transcription of Genes
RNA Splicing
Nuclear Export of RNA
RNA Metabolism
Micro-RNA
Future Directions
Chapter 4: Protein Synthesis, Processing, and Trafficking
Key Words
Protein Synthesis
Regulation of mRNA Translation
Protein Folding
Protein Degradation
Sorting From the Cytosol Into Other Compartments
Cotranslational Protein Translocation in the Endoplasmic Reticulum
Protein Trafficking Within the Secretory Pathway
Specificity of Vesicular Targeting
Future Directions
Chapter 5: Protein Architecture: Relationship of Form and Function
Amino Acids and the Peptide Bond
Chapter 6: Signaling Transduction and Regulation of Cell Metabolism
Signaling Transduction
Regulation of Cell Metabolism
Future Directions
Chapter 7: Pharmacogenomics and Hematologic Diseases
Key Words
Variation in the Human Genome
Single-Nucleotide Polymorphisms
Single-Nucleotide Polymorphisms and Phenotypes
Haplotypes, Linkage Disequilibrium, and Hapmap
Structural Genomic Variants
Somatic Genomic Variants
Catalogues of Genomic Variants, Genotyping Platforms, and Genome-Wide Association Studies
Genetic Variations Influencing Drug Response: Pharmacogenetics–Pharmacogenomics
Optimization of Drug Therapy
Genetic Variations that Influence Drug Disposition
Drug Transporters
Genetic Variations Influencing Drug Targets
Adverse Drug Effects Presenting as Hematologic Disorders
Drug Development
Future Directions
Part II: Cellular Basis of Hematology
Chapter 8: Hematopoietic Stem Cell Biology
Embryonic Origin of Hematopoietic Stem Cells
Definition of Hematopoietic Stem Cells
Functional Assays
Regulation of Hematopoietic Stem Cell Fate
Extrinsic Regulation
Novel Growth Factors for Hematopoietic Stem Cells
Hematopoietic Stem Cell Regeneration
Generating Hematopoietic Stem Cells from Embryonic Stem Cells and Induced Pluripotent Stem Cells
References
Chapter 9: Hematopoietic Microenvironment
Evolution of the Niche Concept
Hematopoieitic Microenvironment during Development
Adult Bone Marrow Microenvironment
Extrinsic Regulation of the Hematopoietic Stem Cell Niche
Lymphoid Niches
Erythroid Niches
Megakaryocytic Niches
Human Bone Marrow Microenvironment
Hematopoieitic Microenvironment in Acute Leukemia and Myelodysplasia
Future Directions
Chapter 10: Cell Adhesion
Key Words
Adhesion Molecules
Extracellular Matrix Proteins
Integrins
Immunoglobulin-Like Receptors
Other Adhesion Receptors That Mediate Protein–protein Interactions
Lectin Adhesion Receptors
Ligand Binding Versus Cell Adhesion
Regulation of Adhesion Receptors
Regulation of Synthesis
Regulation of Surface Expression
Regulation of Binding Affinity
Cell Signaling Through Adhesion Molecules
Cooperative Interactions Between Signaling and Adhesion Molecules
Altered Expression of Adhesion Molecules
Chapter 11: Hematopoietic Cell Trafficking and Chemokines
Chemokines in Control of Leukocyte Trafficking
Leukocyte Entry into Tissues
Chemokine Control of Lymphocyte Homing to Secondary Lymphoid Organs
Trafficking of Leukocytes from Blood into Nonlymphoid Tissues
Migration of Hematopoietic Stem Cells to the Bone Marrow
Leukocyte Migration within Tissues
Positioning of B Cells within Secondary Lymphoid Organs
Leukocyte Exit from Tissues
Future Directions
References
Chapter 12: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization
Hematopoietic Stem and Progenitor Cell Homing
Retention of Hematopoietic Stem and Progenitor Cells in the Bone Marrow
Hematopoietic Stem and Progenitor Cell Mobilization
Future Directions
References
Chapter 13: Vascular Growth in Health and Disease
Hemostatic, Hematopoietic, and Vascular Systems As A Functional Continuum
Constituents of the Vascular System
Processes Involved in Blood Vessel Formation
Mechanisms Triggering Angiogenesis
Therapeutic Implications of Angiogenesis in Hematology
Future Directions
Chapter 14: Principles of Cytokine Signaling
Cytokine and Receptor Families and Signal Transduction
Models of Ligand-Receptor Binding and Activation
Negative Regulators of Cytokine Signaling
Future Directions
Chapter 15: Control of Cell Division
Signal Transduction and Cell Proliferation
The Cell Division Cycle
Rb and Transcriptional Regulation of the Cell Division Cycle
Cyclins, Cyclin-Dependent Kinases, and Cell Cycle Regulation
Entry Into S Phase
Entry Into M Phase
Inhibitors of Cyclin-Dependent Kinases
Cell Cycle Checkpoints
Cell Cycle Alterations with Differentiation
Withdrawal From and Entry Into the Cell Cycle and Cell Differentiation
Coupling of Mandatory Cell Cycle Progression and Cell Differentiation
Specialized Cell Cycle: Endoreplication and Differentiation
Reference
Chapter 16: Cell Death
Physiologic Cell Turnover
Embryogenesis and Sculpting
Executioners of Apoptosis
Activation of Procaspases
Discs, Apoptosomes, Inflammasomes, and Piddosomes
Non-Apoptotic Roles for Caspases
Inhibitor of Apoptosis Proteins
Inhibitor of Apoptosis Protein Antagonists
Core Apoptosis Pathways
BCL-2 Family Proteins and the Intrinsic Pathway of Apoptosis
BAX and BAK and the Mitochondrial Gateway to Apoptosis
BH3-Only Proteins
BCL-2 Family Protein and the Endoplasmic Reticulum Gateway to Apoptosis
Nonapoptotic Roles for BCL-2 Family Proteins
Death Receptor Signaling and the Extrinsic Pathway of Apoptosis
Specific Apoptotic Pathways
Clinical Applications
Future Directions
Part III: Immunologic Basis of Hematology
Chapter 17: Overview and Compartmentalization of the Immune System
Key Words
The Innate Immune System
Immune Deficiency Conditions Caused by Mutations in the Innate Immune System
Innate Immunity and Tissue Homeostasis
Adaptive Immune Response
Cells of the Innate and Adaptive Immune Systems
Anatomy of the Immune System
Encounters with Antigen: the Inflammatory Response
Systemwide Surveillance: the Role of Lymphatic Circulation
Secondary Lymphoid Tissue: Common and Unique Anato
