Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas E-Book , livre ebook

Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas
Second Edition

ROBERT D. ODZE, MD, FRCP(C)
Associate Professor of Pathology, Harvard Medical School
Chief, GI Pathology Service, Brigham and Women’s Hospital, Boston, Massachusetts

JOHN R. GOLDBLUM, MD
Professor of Pathology, Cleveland Clinic Lerner College of Medicine
Chairman, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
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SURGICAL PATHOLOGY OF THE GI TRACT, LIVER, BILIARY TRACT, AND PANCREAS
ISBN: 978-14160-4059-0
Copyright © 2009, 2004 by Saunders, an imprint of Elsevier Inc.
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Rights Department: phone: (+1) 215 239 3804 (US) or (+44) 1865 843830 (UK); fax: (+44) 1865 853333; e-mail: healthpermissions@elsevier.com . You may also complete your request on-line via the Elsevier website at http://www.elsevier.com/permissions .


Notice
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our knowledge, changes in practice, treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the Editors assume any liability for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this book.
The Publisher
Library of Congress Cataloging-in-Publication Data
Surgical pathology of the GI tract, liver, biliary tract, and pancreas / [edited by] Robert D. Odze, John R. Goldblum.—2nd ed.
p.; cm.
Includes bibliographical references and index.
ISBN 978-1-4160-4059-0
1. Gastrointestinal system—Surgery. 2. Liver—Surgery. 3. Biliary tract—Surgery. 4. Pancreas—Surgery. I. Odze, Robert D. II. Goldblum, John R.
[DNLM: 1. Digestive System Surgical Procedures. 2. Pathology, Surgical—methods. 3. Digestive System—physiopathology. WI 900 S9608 2009]
RD540.O396 2009
617.4′3—dc22
2008001963
Acquisitions Editor: William Schmitt
Developmental Editor: Liliana Kim
Publishing Services Manager: Tina Rebane
Senior Project Manager: Linda Lewis Grigg
Design Direction: Karen O’Keefe-Owens
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Dedication
To my family and particularly my late mother, Natasha, who is my hero in life.

ROBERT D. ODZE, MD, FRCP(C)
To those whom I hold most dear: my wife, Asmita; my children, Andrew, Ryan, Janavi, and Raedan; my dear mother, Bette; my late father, Raymond; and the rest of the Goldblum and Shirali families, whom I also cherish.

JOHN R. GOLDBLUM, MD
Contributors

N. Volkan Adsay, MD, Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Vice-Chair and Director, Department of Anatomic Pathology, Emory University Hospital, Atlanta, Georgia
Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract Tumors of the Pancreas and Ampulla of Vater

Lilian B. Antonio, MPH, Laboratory Supervisor, Department of Pathology, Mount Sinai Medical Center, New York, New York
Liver Tissue Processing and Normal Histology

Donald A. Antonioli, MD, Professor of Pathology, Department of Pathology, Harvard Medical School, Consultant and Senior Pathologist, Beth Israel Deaconess Medical Center, Emeritus Consultant in Gastrointestinal Pathology, Children’s Hospital, Boston, Boston, Massachusetts
Polyps of the Small Intestine

May R. Arroyo, MD, PhD, Assistant Professor, Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida
Pediatric Liver Disease and Inherited, Metabolic, and Developmental Disorders of the Pediatric and Adult Liver

Kamran Badizadegan, MD, Assistant Professor of Pathology and Health Sciences and Technology, Harvard Medical School, Assistant Pathologist in Gastrointestinal Pathology, Massachusetts General Hospital, Boston, Massachusetts
Liver Pathology in Pregnancy

Charles Balabaud, MD, Professor of Medicine, Groupe de Recherche pour l’Etude du Foie (GREF), University of Bordeaux 2 Faculty of Medicine, Staff Hepatologist, Hôpital Saint André CHU Bordeaux, Bordeaux, France
Toxic and Drug-Induced Disorders of the Liver

Kenneth P. Batts, MD, Clinical Associate Professor, Department of Pathology, University of Minnesota Medical School, Staff Pathologist, Department of Laboratory Medicine and Pathology, Abbott Northwestern Hospital, Minneapolis, Laboratory Director, Minnesota Gastroenterology, Maplewood, Director of Gastrointestinal Pathology, Hospital Pathology Associates, St. Paul, Minnesota
Autoimmune and Chronic Cholestatic Disorders of the Liver

Ana E. Bennett, MD, Staff Gastrointestinal and Liver Pathologist, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
Inflammatory Disorders of the Esophagus

Paulette Bioulac-Sage, MD, Professor of Medicine, Groupe de Recherche pour l’Etude du Foie (GREF), University of Bordeaux 2 Faculty of Medicine, Staff Pathologist, Pellegrin Hospital and University Hospital, Bordeaux, France
Toxic and Drug-Induced Disorders of the Liver

Elizabeth M. Brunt, MD, Professor, Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, Staff Pathologist, Barnes-Jewish Hospital, St. Louis, Missouri
Fatty Liver Disease

Norman J. Carr, MBBS, FRCPath, FRCPA, Professor of Anatomical Pathology, University of Wollongong Graduate School of Medicine, Wollongong, New South Wales, Australia
Epithelial Neoplasms of the Appendix

Barbara A. Centeno, MD, Professor of Pathology, Department of Oncologic Sciences, University of South Florida College of Medicine, Full Member and Director of Cytopathology Laboratory, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Diagnostic Cytology of the Biliary Tract and Pancreas

James M. Crawford, MD, PhD ASSOCIATE EDITOR, Professor and Chair, Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida
GI Tract Endoscopic and Tissue Processing Techniques and Normal Histology; Gallbladder, Extrahepatic Biliary Tract, and Pancreas Tissue Processing Techniques, and Normal Histology; Cirrhosis; Transplantation Pathology of the Liver; Pediatric Liver Disease and Inherited, Metabolic, and Developmental Disorders of the Pediatric and Adult Liver

Jason A. Daniels, MD, Department of Pathology, Johns Hopkins University School of Medicine; Pathologist, Johns Hopkins Hospital, Baltimore, Maryland
Inflammatory Disorders of the Appendix

Anthony J. Demetris, MD, Starzl Professor of Transplant Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Director, Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Transplantation Pathology of the liver

Theresa S. Emory, MD, Clinical Associate Professor of Pathology, East Tennessee State University James H. Quillen College of Medicine, Johnson City, Tennessee
Epithelial Neoplasms of the Appendix

Francis A. Farraye, MD, MSc, Professor of Medicine, Division of Gastroenterology, Boston University School of Medicine, Clinical Director, Section of Gastroenterology, Boston Medical Center, Boston, Massachusetts
GI Tract Endoscopic and Tissue Processing Techniques and Normal Histology; Screening and Surveillance Guidelines in Gastroenterology

Linda D. Ferrell, MD, Professor and Vice Chair, Department of Pathology, University of California, San Francisco, School of Medicine; Director of Surgical Pathology, Department of Pathology, UCSF Medical Center, San Francisco, California
Benign and Malignant Tumors of the Liver

Judith A. Ferry, MD, Associate Professor, Department of Pathology, Harvard Medical School, Associate Pathologist, James Homer Wright Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts
Lymphoid Tumors of the GI Tract, Hepatobiliary Tract, and Pancreas

Robert M. Genta, MD, FACG, DTM&H, Chief for Academic Affairs, Caris Diagnostics, Inc., Irving, Staff Pathologist, Dallas VA Medical Center, Clinical Professor of Pathology and Medicine (Gastroenterology), University of Texas Southwestern Medical School, Dallas, Clinical Professor of Pathology and Medicine (Gastroenterology), Baylor College of Medicine, Houston, Texas
Inflammatory Disorders of the Stomach

Jonathan N. Glickman, MD, PhD, Assistant Professor, Department of