Sarcoidosis, An Issue of Clinics in Chest Medicine , livre ebook

Sarcoidosis
Clinics In Chest Medicine
Editors
Robert P. Baughman, MD
Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
Daniel A. Culver, DO
Cleveland Clinic Foundation, Cleveland, Ohio, USA

www.chestmed.theclinics.com

Clinics Review Articles

December 2015 Volume 36 Number 4
Table of Contents
Cover image
Title page
Copyright
Contributors
Editors
Authors
CME Accreditation Page
Forthcoming Issues
Forthcoming Issues
Recent Issues
Preface. Sarcoidosis
Cellular Players in the Immunopathogenesis of Sarcoidosis
Key points
Introduction
The innate immune system
The adaptive immune system
Granuloma formation versus fibrosis in sarcoidosis: a consequence of differential immune responses
Perspectives
References
The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis
Key points
Sarcoidosis epidemiology suggests exposure to microbial bioaerosols
Molecular and immunologic investigations reveal microbial proteins and DNA
Immune responses against mycobacterial virulence factors are present in systemic and active sarcoidosis involvement
Noninfectious etiologies of sarcoidosis
Microbial induction of sarcoidosis CD4 + T-cell dysfunction
Clinical trials of antimicrobial therapy in sarcoidosis
Summary
References
Genetics of Sarcoidosis
Key points
Introduction
Summary of approaches taken in genetic epidemiology of sarcoidosis
Genes and regions associated with sarcoidosis
SLC11A1 (NRAMP1, natural resistance-associated macrophage protein gene)
Gene environment interactions in sarcoidosis
Sarcoidosis genetics: a fingerprint of immune-mediated disease
References
The Diagnosis of Sarcoidosis
Key points
Nature of the problem
Definition
Approach to diagnosis
Summary
References
Chest Imaging
Key points
Introduction
Radiographic scoring systems: Scadding staging
Large airway involvement
Mediastinal and hilar lymphadenopathy
Parenchymal involvement
Mycetomas
Pleural involvement
Necrotizing sarcoid granulomatosis
Pulmonary hypertension
Fluorodeoxyglucose F 18 PET/computed tomography
Chest radiograph and fluorodeoxyglucose F 18 PET/computed tomography
High-resolution computed tomography and fluorodeoxyglucose F 18 PET/computed tomography
Summary
References
Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches
Key points
Sarcoidosis: overview and need for biomarkers
Soluble biomarkers associated with monocyte-macrophage activation
Soluble biomarkers associated with lymphocyte origin
Biomarkers associated with fibrosis and extracellular matrix
Emerging strategies for biomarker development
Sarcoidosis biomarkers identified by expression profiling in lung tissues
Gene signatures in blood serve as potential diagnostic tool for sarcoidosis
Distinguishing pulmonary sarcoidosis from tuberculosis by blood gene expression profiling
High-throughput genetic studies to identify novel candidate genes of sarcoidosis
Summary
References
Pulmonary Sarcoidosis
Key points
Introduction
Pathology
Epidemiology
Modes of onset
Pulmonary clinical signs and investigations
Prognostic factors
Evolution
Summary
References
Neurosarcoidosis
Key points
Introduction
Epidemiology and pathology
Clinical presentation
Diagnostic testing
Treatment
Summary
References
Cardiac Sarcoidosis
Key points
Epidemiology and clinical manifestations
Diagnosis
Prognosis
Clinical management: role of immunosuppression
Management of left ventricular dysfunction
Management of conduction abnormalities
Management of ventricular arrhythmias
Risk stratification for sudden cardiac death
Management of atrial arrhythmias
Summary and future directions
References
Ocular Sarcoidosis
Key points
Epidemiology
Clinical manifestations of ocular sarcoidosis
Diagnosis of ocular sarcoidosis
Treatment of ocular sarcoidosis
Prognosis of ocular sarcoidosis
References
Cutaneous Sarcoidosis
Key points
Introduction
Skin pathophysiology
Clinical presentation
Diagnosis and work-up
Differential diagnosis
Treatment
Summary
References
Pulmonary Hypertension in Sarcoidosis
Key points
Introduction
Cause of sarcoidosis-associated pulmonary hypertension
Epidemiology
Diagnosis of sarcoidosis-associated pulmonary hypertension
Treatment
Survival
Summary
References
Severe Sarcoidosis
Key points
Introduction
Severe pulmonary involvement
Severe cardiac involvement and risk stratification
Treatment of severe pulmonary and cardiac sarcoidosis
Summary
References
Consequences of Sarcoidosis
Key points
Introduction
Symptoms
Psychological burden
Treatment options
Rehabilitation
Communication and patient participation
Summary
References
Quality of Life Assessment in Sarcoidosis
Key points
Introduction
The importance of quality of life assessment in sarcoidosis
The assessment of health-related quality of life
Problems in the assessment of health-related quality of life in sarcoidosis
Characteristics of patient-reported outcome measures
Specific health-related quality of life measures used in sarcoidosis
Summary
References
Treatment of Sarcoidosis
Key points
Introduction
Whom to treat
How to treat
Summary
References
Index
Copyright
ELSEVIER
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CLINICS IN CHEST MEDICINE Volume 36, Number 4
December 2015 ISSN 0272-5231, ISBN-13: 978-0-323-40240-8
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