Rapid Review Pharmacology E-Book , livre ebook

Rapid Review Pharmacology
Third Edition

Thomas L. Pazdernik, PhD
Chancellor’s Club Teaching Professor, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas
Laszlo Kerecsen, MD
Professor, Department of Pharmacology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona
Mosby
Front matter
Rapid Review Series
SERIES EDITOR
Edward F. Goljan, MD
BEHAVIORAL SCIENCE, SECOND EDITION
Vivian M. Stevens, PhD; Susan K. Redwood, PhD; Jackie L. Neel, DO; Richard H. Bost, PhD; Nancy W. Van Winkle, PhD; Michael H. Pollak, PhD
BIOCHEMISTRY, THIRD EDITION
John W. Pelley, PhD; Edward F. Goljan, MD
GROSS AND DEVELOPMENTAL ANATOMY, THIRD EDITION
N. Anthony Moore, PhD; William A. Roy, PhD, PT
HISTOLOGY AND CELL BIOLOGY, SECOND EDITION
E. Robert Burns, PhD; M. Donald Cave, PhD
MICROBIOLOGY AND IMMUNOLOGY, THIRD EDITION
Ken S. Rosenthal, PhD; Michael Tan, MD
NEUROSCIENCE
James A. Weyhenmeyer, PhD; Eve A. Gallman, PhD
PATHOLOGY, THIRD EDITION
Edward F. Goljan, MD
PHARMACOLOGY, THIRD EDITION
Thomas L. Pazdernik, PhD; Laszlo Kerecsen, MD
PHYSIOLOGY
Thomas A. Brown, MD
LABORATORY TESTING IN CLINICAL MEDICINE
Edward F. Goljan, MD; Karlis Sloka, DO
USMLE STEP 2
Michael W. Lawlor, MD, PhD
USMLE STEP 3
David Rolston, MD; Craig Nielsen, MD

Rapid Review Pharmacology
Third Edition
Thomas L. Pazdernik, PhD , Chancellor’s Club Teaching Professor, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas
Laszlo Kerecsen, MD , Professor, Department of Pharmacology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona
Copyright

3251 Riverport Lane
Maryland Heights, Missouri 63043
RAPID REVIEW PHARMACOLOGY, Second Edition
Copyright © 2010, 2007, 2003 by Mosby, Inc., an affiliate of Elsevier Inc.
ISBN: 978-0-323-06812-3
All rights reserved . No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Health Sciences Rights Department in Philadelphia, PA, USA: phone: (+1) 215 239 3804, fax: (+1) 215 239 3805, e-mail: healthpermissions@elsevier.com . You may also complete your request on-line via the Elsevier homepage ( http://www.elsevier.com ), by selecting “Customer Support” and then “Obtaining Permissions”.


Notice
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our knowledge, changes in practice, treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the Authors assume any liability for any injury and/or damage to persons or property arising out or related to any use of the material contained in this book.
Library of Congress Cataloging-in-Publication Data
Pazdernik, Thomas.
Rapid review pharmacology / Thomas L. Pazdernik, Laszlo Kerecsen. — 3rd ed.
p. ; cm. — (Rapid review series)
Includes index.
Rev. ed. of: Pharmacology. 2nd ed. c2007.
ISBN 978-0-323-06812-3
I. Pharmacology—Examinations, questions, etc. I. Kerecsen, Laszlo. II. Title.
III. Series: Rapid review series.
[DNLM: 1. Pharmaceutical Preparations—Examination Questions. 2. Pharmaceutical Preparations—Outlines. 3. Drug Therapy—Examination Questions. 4. Drug Therapy— Outlines. QV 18.2 P348r 2011]
RM105.P39 2011
615′.1—dc22
2009045661
Acquisitions Editor: James Merritt
Developmental Editor: Christine Abshire
Publishing Services Manager: Hemamalini Rajendrababu
Project Manager: Nayagi Athmanathan
Design Direction: Steven Stave
Printed in the United States of America
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Dedication
To my wife, Betty; my daughter Nancy and my granddaughter Rebecca Irene; my daughter Lisa and her husband, Chris; and my triplet grandchildren, Cassidy Rae, Thomas Pazdernik, and Isabel Mari
TLP
To Gabor and Tamas, my sons
LK
Series Preface
The First and Second Editions of the Rapid Review Series have received high critical acclaim from students studying for the United States Medical Licensing Examination (USMLE) Step 1 and consistently high ratings in First Aid for the USMLE Step 1 . The new editions will continue to be invaluable resources for time-pressed students. As a result of reader feedback, we have improved upon an already successful formula. We have created a learning system, including a print and electronic package, that is easier to use and more concise than other review products on the market.

Special features

Book

• Outline format: Concise, high-yield subject matter is presented in a study-friendly format.
• High-yield margin notes: Key content that is most likely to appear on the exam is reinforced in the margin notes.
• Visual elements: Full-color photographs are utilized to enhance your study and recognition of key pathology images. Abundant two-color schematics and summary tables enhance your study experience.
• Two-color design: Colored text and headings make studying more efficient and pleasing.

New! Online Study and Testing Tool

• A minimum of 350 USMLE Step 1−type MCQs: Clinically oriented, multiple-choice questions that mimic the current USMLE format, including high-yield images and complete rationales for all answer options.
• Online benefits: New review and testing tool delivered via the USMLE Consult platform, the most realistic USMLE review product on the market. Online feedback includes results analyzed to the subtopic level (discipline and organ system).
• Test mode: Create a test from a random mix of questions or by subject or keyword using the timed test mode . USMLE Consult simulates the actual test-taking experience using NBME's FRED interface, including style and level of difficulty of the questions and timing information. Detailed feedback and analysis shows your strengths and weaknesses and allows for more focused study.
• Practice mode: Create a test from randomized question sets or by subject or keyword for a dynamic study session. The practice mode features unlimited attempts at each question, instant feedback, complete rationales for all answer options, and a detailed progress report.
• Online access: Online access allows you to study from an internet-enabled computer wherever and whenever it is convenient. This access is activated through registration on www.studentconsult.com with the pin code printed inside the front cover.

Student Consult

• Full online access: You can access the complete text and illustrations of this book on www.studentconsult.com .
• Save content to your PDA: Through our unique Pocket Consult platform, you can clip selected text and illustrations and save them to your PDA for study on the fly!
• Free content: An interactive community center with a wealth of additional valuable resources is available.
Acknowledgment of Reviewers
The publisher expresses sincere thanks to the medical students and faculty who provided many useful comments and suggestions for improving both the text and the questions. Our publishing program will continue to benefit from the combined insight and experience provided by your reviews. For always encouraging us to focus on our target, the USMLE Step 1, we thank the following:
Patricia C. Daniel, PhD, Kansas University Medical Center
Steven J. Engman, Loyola University Chicago Stritch School of Medicine
Omar A. Khan, University of Vermont College of Medicine
Michael W. Lawlor, Loyola University Chicago Stritch School of Medicine
Lillian Liang, Jefferson Medical College
Erica L. Magers, Michigan State University College of Human Medicine
Acknowledgments

Thomas L. Pazdernik, PhD, Laszlo Kerecsen, MD
The authors wish to acknowledge Jim Merritt, Senior Acquisitions Editor, Christine Abshire, Developmental Editor, and Nayagi Athmanathan, Project Manager, at Elsevier. We also thank Eloise DeHann for editing the text and Matt Chansky for his excellent illustrations. A very special thanks to Dr. Edward F. Goljan, Series Editor, who read each chapter quickly after it was sent to him and provided both valuable editing and suggestions for marked improvements to each chapter. We give thanks to Tibor Rozman, MD, for his contributions to the development of clinically relevant questions and to Tamas Kerecsen for processing the questions. We also thank the faculty of the Department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center and the faculty of the Department of Pharmacology at Arizona College of Osteopathic Medicine, Midwestern University, for their superb contributions to the development of materials for our teaching programs. Dr. Lisa Pazdernik, Ob/Gyn provided valuable input into Chapter 26 (Drugs used in Reproductive Endocrinology). Finally, we thank the numerous medical students who, over the years, have been our inspiration for developing teaching materials.
Table of Contents
Instructions for online access
Front matter
Copyright
Dedication
Series Preface
Acknowledgment of Reviewers
Acknowledgments
SECTION I: Principles of Pharmacology
Chapter 1: Pharmacokinetics
Chapter 2: Pharmacodyn