Rapid Review Biochemistry E-Book , livre ebook

Rapid Review Biochemistry
Third Edition

John W. Pelley, PhD
Associate Professor, Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas

Edward F. Goljan, MD
Professor of Pathology, Department of Pathology, Oklahoma State University Center for Health Sciences, College of Osteopathic Medicine, Tulsa, Oklahoma
Mosby
Front matter
RAPID REVIEW BIOCHEMISTRY
Rapid Review Series
SERIES EDITOR
Edward F. Goljan, MD
BEHAVIORAL SCIENCE, SECOND EDITION
Vivian M. Stevens, PhD; Susan K. Redwood, PhD; Jackie L. Neel, DO; Richard H. Bost, PhD; Nancy W. Van Winkle, PhD; Michael H. Pollak, PhD
BIOCHEMISTRY, THIRD EDITION
John W. Pelley, PhD; Edward F. Goljan, MD
GROSS AND DEVELOPMENTAL ANATOMY, THIRD EDITION
N. Anthony Moore, PhD; William A. Roy, PhD, PT
HISTOLOGY AND CELL BIOLOGY, SECOND EDITION
E. Robert Burns, PhD; M. Donald Cave, PhD
MICROBIOLOGY AND IMMUNOLOGY, THIRD EDITION
Ken S. Rosenthal, PhD; Michael J. Tan, MD
NEUROSCIENCE
James A. Weyhenmeyer, PhD; Eve A. Gallman, PhD
PATHOLOGY, THIRD EDITION
Edward F. Goljan, MD
PHARMACOLOGY, THIRD EDITION
Thomas L. Pazdernik, PhD; Laszlo Kerecsen, MD
PHYSIOLOGY
Thomas A. Brown, MD
LABORATORY TESTING IN CLINICAL MEDICINE
Edward F. Goljan, MD; Karlis Sloka, DO
USMLE STEP 2
Michael W. Lawlor, MD, PhD
USMLE STEP 3
David Rolston, MD; Craig Nielsen, MD

RAPID REVIEW BIOCHEMISTRY
THIRD EDITION
John W. Pelley, PhD , Associate Professor, Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas
Edward F. Goljan, MD , Professor of Pathology, Department of Pathology, Oklahoma State University Center for Health Sciences, College of Osteopathic Medicine, Tulsa, Oklahoma
Copyright

1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
RAPID REVIEW BIOCHEMISTRY, Third Edition
ISBN: 978-0-323-06887-1
Copyright 2011, 2007, 2003 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Rights Department: phone: (+1) 215 239 3804 (US) or (+44) 1865 843830 (UK); fax: (+44) 1865 853333; e-mail: healthpermissions@elsevier.com . You may also complete your request on-line via the Elsevier website at http://www.elsevier.com/permissions .

Notice
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our knowledge, changes in practice, treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the Authors assumes any liability for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this book.
The Publisher
Library of Congress Cataloging-in-Publication Data
Pelley, John W.
Rapid review biochemistry / John W. Pelley, Edward F. Goljan. – 3rd ed.
p. ; cm. – (Rapid review series)
Rev. ed. of: Biochemistry. 2nd ed. c2007.
ISBN 978-0-323-06887-1
1. Biochemistry–Outlines, syllabi, etc. 2. Biochemistry–Examinations, questions, etc. I. Goljan, Edward F. II. Pelley, John W. Biochemistry. III. Title. IV. Series: Rapid review series.
[DNLM: 1. Metabolism–Examination Questions. 2. Biochemical Phenomena–Examination Questions. 3. Nutritional Physiological Phenomena–Examination Questions. QU 18.2 P389r 2011]
QP518.3.P45 2011
612′.015–dc22
2009045666
Acquisitions Editor: James Merritt
Developmental Editor: Christine Abshire
Publishing Services Manager: Hemamalini Rajendrababu
Project Manager: K Anand Kumar
Design Direction: Steve Stave

Printed in the United States of America
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Series Preface
The first and second editions of the Rapid Review Series have received high critical acclaim from students studying for the United States Medical Licensing Examination (USMLE) Step 1 and consistently high ratings in First Aid for the USMLE Step 1 . The new editions will continue to be invaluable resources for time-pressed students. As a result of reader feedback, we have improved on an already successful formula. We have created a learning system, including a print and electronic package, that is easier to use and more concise than other review products on the market.

SPECIAL FEATURES

Book

• Outline format: Concise, high-yield subject matter is presented in a study-friendly format.
• High-yield margin notes: Key content that is most likely to appear on the examination is reinforced in the margin notes.
• Visual elements: Full-color photographs are used to enhance students’ study and recognition of key pathology images. Abundant two-color schematics and summary tables enhance the study experience.
• Two-color design: Colored text and headings make studying more efficient and pleasing.

New Online Study and Testing Tool

• More than 350 USMLE step 1–type multiple-choice questions: Clinically oriented, multiple-choice questions mimic the current USMLE format, including high-yield images and complete rationales for all answer options.
• Online benefits: New review and testing tool delivered by the USMLE Consult platform, the most realistic USMLE review product on the market. Online feedback includes results analyzed to the subtopic level (discipline and organ system).
• Test mode: A test can be created from a random mix of questions or generated by subject or keyword using the timed test mode. USMLE Consult simulates the actual test-taking experience using NBME’s FRED interface, including style and level of difficulty of the questions and timing information. Detailed feedback and analysis highlights strengths and weaknesses and enables more focused study.
• Practice mode: A test can be created from randomized question sets or fashioned by subject or keyword for a dynamic study session. The practice mode features unlimited attempts at each question, instant feedback, complete rationales for all answer options, and a detailed progress report.
• Online access: Online access allows students to study from an Internet-enabled computer wherever and whenever it is convenient. This access is activated through registration on www.studentconsult.com with the pin code printed inside the front cover.

Student Consult

• Full online access: The complete text and illustrations of this book can be obtained at www.studentconsult.com .
• Save content to a PDA: Through our unique Pocket Consult platform, students can clip selected text and illustrations and save them to a PDA for study on the fly!
• Free content: An interactive community center with a wealth of additional valuable resources is available.
Acknowledgment of Reviewers
The publisher expresses sincere thanks to the medical students who provided many useful comments and suggestions for improving the text and the questions. Our publishing program will continue to benefit from the combined insight and experience provided by your reviews. For always encouraging us to focus on our target, the USMLE Step 1, we thank the following:
Thomas A. Brown, West Virginia University School of Medicine
Patricia C. Daniel, PhD, Kansas University Medical Center
John A. Davis, PhD, Yale University School of Medicine
Daniel Egan, Mount Sinai School of Medicine
Steven J. Engman, Loyola University Chicago Stritch School of Medicine
Michael W. Lawlor, Loyola University Chicago Stritch School of Medicine
Craig Wlodarek, Rush Medical College
Acknowledgments
In a way, an author begins to work on a book long before he sits down at a word processor. Lessons learned in the past from my own teachers and mentors, discussions with colleagues and students, and daily encouragement from family and friends have contributed greatly to the writing of this book.
My wife, MJ, has been a constant source of love and support. Her sensitivity made me aware that I was ready to write this book, and she allowed me to take the time I needed to complete it.
The many caring, intelligent students whom I have taught at Texas Tech over the years have inspired me to hone my thinking, teaching, and writing skills, all of which affected the information that went into the book and the manner in which it was presented.
John A. Davis, MD, PhD, Çağatay H. Ersahin, MD, PhD, Anna M. Szpaderska, DDS, PhD are thanked for their input in previous editions, which continues to add value to