Psoriatic Arthritis, An Issue of Rheumatic Disease Clinics 41-4 , livre ebook

Clinics Review Articles Rheumatic Disease Clinics of North America
Psoriatic Arthritis

Christopher T. Ritchlin, MD, MPH
Allergy Immunology and Rheumatology Division, University of Rochester Medical Center, Rochester, New York
ISSN  0889-857X Volume 41 • Number 4 • November 2015
Elsevier
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editor
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword: Psoriatic Arthritis
Preface: Psoriatic Arthritis
The Epidemiology of Psoriatic Arthritis
Key points
Introduction
Methods
Prevalence and incidence of psoriatic arthritis in the population
Prevalence and incidence of psoriatic arthritis among patients with psoriasis
Alternative diagnoses, missed diagnoses, and misclassification in studies of psoriatic arthritis
Defining and classifying psoriatic arthritis
Psoriatic arthritis is a heterogeneous disease
Psoriatic arthritis in children
Recognition of early psoriatic arthritis
Subclinical disease in patients with psoriasis
Improving detection of psoriatic arthritis among patients with psoriasis
Comorbidities in psoriatic arthritis
Summary
Clinical Features and Diagnostic Considerations in Psoriatic Arthritis
Key points
Clinical features of psoriatic arthritis
Summary
Natural History, Prognosis, and Socioeconomic Aspects of Psoriatic Arthritis
Key points
Introduction
Natural history
Prognosis
Morbidity
Mortality
Summary
Imaging in Psoriatic Arthritis
Key points
Introduction
Conventional radiography
Computed tomography
Ultrasonography
MRI
Summary
Early Psoriatic Arthritis
Key points
Introduction
Risk factors for psoriatic arthritis in psoriasis
Clinical presentation of early disease
Summary
Genetic, Epigenetic and Pharmacogenetic Aspects of Psoriasis and Psoriatic Arthritis
Key points
Genetics of psoriatic disease
Epigenetics of psoriasis and psoriatic arthritis susceptibility
Pharmacogenetics of psoriatic disease
Summary
Etiology and Pathogenesis of Psoriatic Arthritis
Key points
Genetic factors
Environmental factors
Microbiome
Role of obesity
Immunopathology: historical context
Establishing a role for interleukin-17 in psoriatic arthritis
Skin
Nails
Enthesis
Dactylitis
Synovium
Altered bone remodeling in psoriatic arthritis
Animal models
Summary
Etiology and Pathogenesis of Psoriasis
Key points
Introduction
Etiology
Psoriasis susceptibility loci
Pathogenesis
Toward defining distinct psoriatic entities
Psoriasis as a chronic systemic disease
Summary
Comorbidities in Psoriatic Arthritis
Key points
Introduction
Cardiovascular disease
Obesity
Diabetes
Ophthalmic disease
Depression and anxiety
Inflammatory bowel disease
Liver disease
Osteoporosis
Kidney disease
Malignancy
Infection
Summary
Outcome Measures in Psoriatic Arthritis
Key points
Introduction
Domains
Arthritis
Skin
Nails
Enthesitis
Dactylitis
Axial disease
Patient-reported outcomes: quality of life, function, fatigue, impact of disease
Composite measures
Future considerations/summary
Management of Psoriatic Arthritis
Key points
Introduction
Traditional disease-modifying rheumatic agents
Traditional disease-modifying antirheumatic drugs in combination with tumor necrosis factor inhibitors
Targeted synthetic disease-modifying antirheumatic drugs (small molecules)
Summary
Biologic Therapy for Psoriatic Arthritis
Key points
Introduction
Tumor necrosis factor inhibition
Costimulatory blockade modulating T-lymphocyte function
Interleukin-6 inhibition
B-lymphocyte inhibition
Targeting the T-helper 17 cell axis in psoriatic arthritis
Interleukin-12 to interleukin-23 inhibitors
Interleukin-17 inhibitors
Interleukin-23 inhibitors
Therapeutic strategies with biologic therapy
Summary
Novel Treatment Concepts in Psoriatic Arthritis
Key points
Introduction
Early intervention
Disease-specific considerations
Modifications to the treatment paradigm
Summary
Index
Copyright
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RHEUMATIC DISEASE CLINICS OF NORTH AMERICA Volume 41, Number 4
November 2015 ISSN 0889-857X, ISBN 13: 978-0-323-41352-7
Editor: Jennifer Flynn-Briggs
Developmental Editor: Casey Jackson
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Contributors

Consulting Editor
MICHAEL H. WEISMAN, MD
Cedars-Si