Practical Soft Tissue Pathology: A Diagnostic Approach E-Book , livre ebook

Practical Soft Tissue Pathology
A Diagnostic Approach

Jason L. Hornick, MD, PhD
Director of Surgical Pathology, Director, Immunohistochemistry Laboratory, Brigham and Women’s Hospital, Associate Professor of Pathology, Harvard Medical School, Boston, Massachusetts
Saunders
Table of Contents
Cover image
Title page
Series page
Copyright
Dedication
Contributors
Series Preface
Preface
Acknowledgments
Pattern-Based Approach to Diagnosis
Chapter 1: Introduction: Tumor Classification and Immunohistochemistry
Tumor Classification
Immunohistochemistry
Chapter 2: Biologic Potential, Grading, Staging, and Reporting of Sarcomas
Biologic Potential
Sarcoma Grading
Sarcoma Staging
Surgical Margins
Chapter 3: Spindle Cell Tumors of Adults
General Concepts
Nonmesenchymal Neoplasms with Spindle Cell Cytomorphology
Nodular Fasciitis and Similar Pseudosarcomatous Myofibroblastic Lesions
Myofibroma and Myopericytoma
Phosphaturic Mesenchymal Tumor
Myofibroblastoma and Variants
Fibroma
Calcifying Fibrous Tumor
Angiofibroma of Soft Tissue
Fibrous Histiocytoma and Variants
Solitary Fibrous Tumor and Variants
Fibromatoses
Spindle Cell Lipoma
Spindle Cell Liposarcoma
Schwannoma and Variants
Neurofibroma
Perineurioma
Ganglioneuroma
Benign Smooth Muscle Tumors
Leiomyosarcoma
Epstein-Barr Virus–Associated Smooth Muscle Neoplasm
Lymphangiomyoma and Lymphangiomyomatosis
Angiomatoid Fibrous Histiocytoma
Synovial Sarcoma
Malignant Peripheral Nerve Sheath Tumor
Sarcomas with Fibroblastic Differentiation
Low-Grade Myofibroblastic Sarcoma
Spindle Cell Rhabdomyosarcoma
Clear Cell Sarcoma
Pseudomyogenic Hemangioendothelioma
Unclassified Spindle Cell Sarcomas
Chapter 4: Pediatric Spindle Cell Tumors
Fibroblastic-Myofibroblastic Tumors
Other Spindle Cell Tumors of Childhood and Adolescence
Chapter 5: Tumors with Myxoid Stroma
Ganglion Cyst
Intramuscular/Cellular Myxoma
Juxta-Articular Myxoma
Dermal Nerve Sheath Myxoma
Superficial Acral Fibromyxoma (Digital Fibromyxoma)
Superficial Angiomyxoma
Deep Angiomyxoma
Ossifying Fibromyxoid Tumor
Myoepithelioma and Myoepithelial Carcinoma
Myxofibrosarcoma
Myxoid Liposarcoma
Extraskeletal Myxoid Chondrosarcoma
Low-Grade Fibromyxoid Sarcoma
Myxoinflammatory Fibroblastic Sarcoma
Myxoid Nerve Sheath Tumors
Other Tumors with Myxoid Stroma
Chapter 6: Epithelioid and Epithelial-like Tumors
Approach to the Diagnosis of Epithelioid Tumors of Soft Tissue
Epithelioid Hemangioma
Glomus Tumor
Myoepithelioma/Mixed Tumor/Myoepithelial Carcinoma of Soft Tissue
PEComa of Soft Tissue
Adult-Type Rhabdomyoma
Benign Epithelioid Peripheral Nerve Sheath Tumor (Epithelioid Schwannoma)
Granular Cell Tumor
Sclerosing Perineurioma
Extracranial Meningioma
Ossifying Fibromyxoid Tumor
Ependymoma of Soft Tissue
Alveolar Soft Part Sarcoma
Epithelioid Hemangioendothelioma
Epithelioid Sarcoma
Extrarenal Malignant Rhabdoid Tumor
Sclerosing Epithelioid Fibrosarcoma
Epithelioid and Epithelial-like Variants of Other Sarcomas
Epithelioid Angiosarcoma
Epithelioid Malignant Peripheral Nerve Sheath Tumor
Epithelioid Gastrointestinal Stromal Tumor
Epithelioid Myxofibrosarcoma
Pleomorphic Liposarcoma, Epithelioid Variant
Synovial Sarcoma, Epithelial/Glandular Variant
Glandular Malignant Peripheral Nerve Sheath Tumor
Other Epithelioid Variants of Specific Sarcomas
Chapter 7: Pleomorphic Sarcomas
Atypical Fibroxanthoma
Pleomorphic Hyalinizing Angiectatic Tumor
Undifferentiated Pleomorphic Sarcoma
Myxofibrosarcoma
Pleomorphic Myogenic Sarcomas
Pleomorphic Lipogenic Sarcomas
Extraskeletal Osteosarcoma
Myxoinflammatory Fibroblastic Sarcoma
Malignant Mesenchymoma
Algorithmic Approach When Confronted with a Pleomorphic Sarcomatoid Neoplasm
Grading of Pleomorphic Sarcomas
The Role of Imaging Studies in the Diagnosis of Pleomorphic Sarcomas
Chapter 8: Round Cell Tumors
The Role of Immunohistochemistry and Molecular Genetics
How Should Small Round Cell Sarcoma Samples Be Handled?
Should Molecular Techniques to Detect Translocations Always Be Performed?
Ewing Sarcoma/Primitive Neuroectodermal Tumor
Alveolar Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma
“Round Cell” Liposarcoma
Desmoplastic Small Round Cell Tumor
Poorly Differentiated Synovial Sarcoma, Round Cell Variant
Undifferentiated Round Cell Sarcoma
Chapter 9: Biphasic Tumors and Tumors with Mixed Patterns
Biphasic Synovial Sarcoma
Mixed Tumor/Myoepithelioma/Myoepithelial Carcinoma
Malignant Peripheral Nerve Sheath Tumor with Divergent (Heterologous) Differentiation (Including Glandular Type)
Ectopic Hamartomatous Thymoma
Gastrointestinal Stromal Tumor, Mixed Type
Dedifferentiated Liposarcoma
Melanotic Neuroectodermal Tumor of Infancy
Nonmesenchymal Tumors with Biphasic and Mixed Patterns
Chapter 10: Soft Tissue Tumors with Prominent Inflammatory Cells
Inflammatory Myofibroblastic Tumor
Inflammatory Leiomyosarcoma
Histiocytic and Dendritic Cell Tumors
Angiomatoid Fibrous Histiocytoma
Myxoinflammatory Fibroblastic Sarcoma
Well-Differentiated Inflammatory Liposarcoma
Inflammatory Malignant Fibrous Histiocytoma
Mass-Forming Idiopathic Fibroinflammatory Disorders
Chapter 11: Giant Cell–Rich Tumors
Tenosynovial Giant Cell Tumors
Tumors of Superficial Soft Tissues
Giant Cell–Rich Sarcomas and Histologic Mimics
Chapter 12: Adipocytic Tumors
Lipoma
Lipofibromatosis
Lipomatosis of Nerve
Angiolipoma
Spindle Cell/Pleomorphic Lipoma
Hemosiderotic Fibrolipomatous Tumor
Lipoblastoma/Lipoblastomatosis
Hibernoma
Myolipoma
Chondroid Lipoma
Liposarcoma
Atypical Lipomatous Tumors/Well-Differentiated Liposarcoma
Dedifferentiated Liposarcoma
Myxoid Liposarcoma
Pleomorphic Liposarcoma
Chapter 13: Vascular Tumors
Immunohistochemistry
Classification of Vascular Tumors
Vasoformative Pattern
Epithelioid Lesions
Spindle Cell Lesions
Chapter 14: Cartilaginous and Osseous Soft Tissue Tumors
Myositis Ossificans and Heterotopic Ossification
Fibro-osseous Pseudotumor of the Digits
Fibrodysplasia Ossificans Progressiva
Tumoral Calcinosis and Tumoral Calcinosis–like Lesions
Soft Tissue Chondroma
Synovial Chondromatosis
Soft Tissue Aneurysmal Bone Cyst
Extraskeletal Myxoid Chondrosarcoma
Extraskeletal Mesenchymal Chondrosarcoma
Extraskeletal Osteosarcoma
Neoplasms Showing Heterologous Osteocartilaginous Differentiation
Chapter 15: Cutaneous Mesenchymal Tumors
Spindle Cell Tumors
Myxoid Tumors
Epithelioid Tumors
Pleomorphic Tumors
Adipocytic Tumors
Chapter 16: Mesenchymal Tumors of the Gastrointestinal Tract
Gastrointestinal Stromal Tumor
Leiomyoma
Leiomyosarcoma
Schwannoma
Gastrointestinal Clear Cell Sarcoma–like Tumor
Inflammatory Myofibroblastic Tumor
Desmoid Fibromatosis
Inflammatory Fibroid Polyp
Plexiform Fibromyxoma
Perivascular Epithelioid Cell Tumor (PEComa)
Glomus Tumor
Polypoid Ganglioneuroma and Ganglioneuromatosis
Granular Cell Tumor
Mucosal Perineurioma
Mucosal Schwann Cell Hamartoma
Chapter 17: Lower Genital Soft Tissue Tumors
General Approach to Soft Tissue Lesions of the Lower Genital Tract
Deep (Aggressive) Angiomyxoma
Fibroepithelial Stromal Polyp
Angiomyofibroblastoma
Cellular Angiofibroma
Prepubertal Vulval Fibroma
Mammary-Type Myofibroblastoma
Spindle Cell Epithelioma
Genital Rhabdomyoma
Genital Smooth Muscle Tumors
Chapter 18: Applications of Molecular Testing to Differential Diagnosis
Genetic Classification of Sarcomas
Approaches to Molecular Diagnostics
Molecular Features of Particular Entities
Practical Applications of Molecular Diagnostic Testing
Significance of Detecting an EWSR1 Gene Rearrangement by FISH
Conclusions
Index
Series page
Pattern Recognition Series
Series editors: Kevin O. Leslie and Mark R. Wick
Practical Breast Pathology
Edited by Kristen A. Atkins and Christina S. Kong
Practical Cytopathology
Edited by Matthew Zarka and Barbara Centeno
Practical Skin Pathology
Written by James W. Patterson
Practical Hepatic Pathology
Edited by Romil Saxena
Practical Pulmonary Pathology, Second Edition
Edited by Kevin O. Leslie and Mark R. Wick
Practical Renal Pathology
Edited by Donna J. Lager and Neil A. Abrahams
Practical Soft Tissue Pathology
Edited by Jason L. Hornick
Practical Surgical Neuropathology
Edited by Arie Perry and Daniel J. Brat
Copyright

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PRACTICAL SOFT TISSUE PATHOLOGY: A DIAGNOSTIC APPROACH  ISBN 978-1-4160-5455-9
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