Comprehensive Cytopathology E-Book , livre ebook

COMPREHENSIVE CYTOPATHOLOGY
Third Edition

Marluce Bibbo, MD ScD FIAC FASCP
Professor of Pathology and Cell Biology, Jefferson Medical College, Director, Cytopathologym, Thomas Jefferson University Hospital, Philadelphia, PA, USA

David Wilbur, MD
Associate Professor of Pathology, Harvard Medical School, Director, Cytopathology, Massachusetts General Hospital, Boston, MA, USA
SAUNDERS
Copyright
First edition 1991
Second edition 1997
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Notice
Medical knowledge is constantly changing. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the Publisher nor the author assume any liability for any injury and/or damage to persons or property arising from this publication.
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Contributors

Fadi W. Abdul-Karim, MD, Associate Professor of Pathology and Orthopedics, Department of Pathology, University Hospitals of Cleveland, Cleveland, OH, USA

Tahseen Al-Saleem, MD, Director of Hematopathology and Flow Cytometry, Senior Member, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA, USA

Anniek J.M. van Aspert – van Erp, PhD CFIAC, Research Associate, Department of Pathology, University of Nijmegen, Ravenstein, The Netherlands

Peter H. Bartels, PhD, Professor Emeritus of Optical Sciences, Department of Optical Sciences, University of Arizona, Tucson, AZ, USA

Simon Bergman, MD, Associate Professor of Pathology, Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC, USA

Marluce Bibbo, MD ScD FIAC FASCP, Professor of Pathology and Cell Biology, Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, TJU, Director of Cytopathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA

Sandra H. Bigner, MD, Medical Director, Laboratory Corporation of America, Burlington, NC, USA

Lukas Bubendorf, MD, Professor of Pathology, Institute for Pathology, Division of Cytology, University Hospital Basel, Basel, Switzerland

Johan Bulten, MD PhD MIAC, Assistant Professor of Pathology, Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

Alicia L. Carter, MD, Fellow Cytopathology, Duke University Medical Center, Burlington, NC, USA

Mamatha Chivukula, MD, Assistant Professor of Pathology, Magee-Womens Hospital of UPMC, Pittsburg, PA, USA

Luiz M. Collaço, MD, Professor of Pathology, Federal University of Parana, Evangelica Faculty of Parana, Bigorrilho, Curitiba, Brazil

Terence J. Colgan, MD, Professor of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, Toronto, ON, Canada

David J. Dabbs, MD, Professor and Chief of Pathology, Department of Pathology, Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA

Magnus von Knebel Doeberitz, MD, Professor of Pathology, Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany

Craig E. Elson, MD FCAP, Director of Cytopathology, Department of Pathology, Research Medical Center, HCA Midwest Division, Kansas City, MO, USA

Michael S. Facik, MPA CT(ASCP), Cytopathology Laboratory Supervisor, Department of Cytopathology, University of Rochester Medical Center, Rochester, NY, USA

Brendan T. Fitzpatrick, MD, Attending Pathologist, Our Lady of Lourdes Medical Center, Camden, NJ, USA

William J. Frable, MD, Professor of Pathology, Virginia Commonwealth University, Richmond, VA, USA

Hugo Galera-Davidson, MD FIAC, Professor of Pathology, Faculty of Medicine, University of Seville, Hospital Universitario Virgen Macarena, Seville, Spain

Kim R. Geisinger, MD FCAP, Professor of Pathology, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Ben J. Glasgow, MD, Associate Professor of Ophthalmology and Pathology, Department of Pathology, UCLA Center for Health Sciences, Los Angeles, CA, USA

Katharina Glatz-Krieger, MD, Professor of Pathology, University Hospital of Basel, Basel, Switzerland

Ricardo González-Cámpora, MD FIAC, Professor of Pathology, Faculty of Medicine, University of Seville, Hospital Universitario Virgen Macarena, Seville, Spain

Hans Jurgen Grote, MD, Assistant Professor, Institute of Cytopathology, Heinrich-Heine University, Dusseldorf, Germany

Prabodh K. Gupta, MD FIAC, Professor, Pathology and Laboratory Medicine, Cytopathology and Cytometry Section, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Pierre Heimann, MD PhD, Pathologist, Service d'Anatomie Pathologique, Cytologie, Cytogénétique, Institut Jules Bordet, Brussels, Belgium

William W. Johnston, MD FIAC, Professor Emeritus of Pathology, Duke University, Durham, NC, USA

Ruth L. Katz, MD, Professor of Pathology, Director, Image Analysis and Research Cytopathology, Department of Pathology, MD Anderson Hospital, Houston, TX, USA

Catherine M. Keebler, ScD(hon) CFIAC, Registrar, International Academy of Cytology, Chicago, IL, USA

William H. Kern, MD FIAC, Clinical Professor Emeritus of Pathology, Department of Pathology, LAC/USC Medical Center, Pasadena, CA, USA

Larry F. Kluskens, MD PhD, Assistant Professor, Director of Cytology, Department of Pathology, Rush University Medical Center, Chicago, IL, USA

Savitri Krishnamurthy, MD, Associate Professor, Department of Cytopathology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA

Oscar Lin, MD PhD, Associate Attending, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

Diane B. Mandell, CT (ASCP) CFIAC, Supervisor, Cytology Service, Center for the Health Sciences, University of California at Los Angeles, Los Angeles, CA, USA

Cindy McGrath, MD, Assistant Professor of Pathology and Laboratory Medicine, Cytopathology Section, University of Pennsylvania Medical Center, Philadelphia, PA, USA

C. Meg McLachlin, MD, Associate Professor, Pathology and OBGYN, University of Western Ontario, Medical Leader, Surgical Pathology, London Health Sciences Centre, London, ON, Canada,

Christopher R.B. Merritt, MD, Professor of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA

Kiran F. Narsinh, MD, Fellow Eye Pathology, Department of Pathology, JSEI,UCLA Medical Center, Los Angeles, CA, USA

Joseph F. Nasuti, MD, Attending Pathologist, Dianon Systems, Division of LabCorp, Bridgeport, CT, USA

Ritu Nayar, MD, Associate Professor of Pathology, Northwestern University, Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA

Bernard Naylor, MB ChB FIAC, Professor Emeritus of Pathology, The University of Michigan, Ann Arbor, MI, USA

Wai-Kuen Ng, MBBS FRCPA FHKCPath FHKAM(Pathology) FIAC, Honorary Clinical Associate Professor, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China

José Schalper Perez, MD MIAC, Professor of Pathology, San Sebastian University School of Medicine, Chief, Division of Anatomical Pathology and Cytopathology, Concepcion, Chile

Reda S. Saad, MD PhD, Associate Professor, Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA, USA

Jan F. Silverman, MD FCAP, Professor and Chairman, Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA, USA

Lambert Skoog, MD PhD, Professor of Clinical Cytology, Department of Pathology and Clinical Cytology, Karolinska University Hospital Solna, Stockholm, Sweden

Diane Solomon, MD, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Theresa M. Somrak, JD CT(ASCP) CFIAC, Director, Cytopathology Education Consortium Activities, Chicago, IL, USA

Kari Syrjanen, MD PhD FIAC, Professor, Department