Aeroallergen and Food Immunotherapy, An Issue of Immunology and Allergy Clinics of North America , livre ebook

Aeroallergen and Food Immunotherapy
Immunology and Allergy Clinics of North America
Editors
Anna H. Nowak-W grzyn, MD
Pediatrics, Icahn School of Medicine at Mount Sinai, Jaffe Family Food Allergy Institute, New York, NY, USA
Linda S. Cox, MD
Department of Medicine, Nova Southeastern University Davie Florida, Ft. Lauderdale, FL, USA
Consulting Editor
Stephen A. Tilles

Clinics Review Articles

www.immunology.theclinics.com

February 2016 Volume 36 Number 1
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editors
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword. Allergen Immunotherapy-An Old Friend Coming of Age
Preface. Allergen-specific Immunotherapy-Turning the Tables on the Immune System
References
Allergen Immunotherapy: History and Future Developments
Key points
The historical perspective
The present situation
The near future: perspectives
Unmet needs and concluding remarks
References
Subcutaneous Immunotherapy and Sublingual Immunotherapy: Comparative Efficacy, Current and Potential Indications, and Warnings-United States Versus Europe
Key points
Introduction
Clinical efficacy
The immunologic response
Disease modification
Defined optimal doses
Multiallergen allergy immunotherapy
Safety
Comparative efficacy of subcutaneous immunotherapy and sublingual immunotherapy
Warnings
References
Novel Delivery Routes for Allergy Immunotherapy: Intralymphatic, Epicutaneous, and Intradermal
Key points
Introduction
Intralymphatic allergen-specific immunotherapy
Allergen-specific epicutaneous immunotherapy
Intradermal allergen immunotherapy
Summary and future directions
References
Advances in the Treatment of Food Allergy: Sublingual and Epicutaneous Immunotherapy
Key points
Introduction
Sublingual immunotherapy
Sublingual immunotherapy versus oral immunotherapy
Epicutaneous immunotherapy
Summary
References
Oral Immunotherapy for Food Allergy
Key points
Introduction
What is oral immunotherapy?
Efficacy of oral immunotherapy
Summary of clinical trials
Multiple foods
Immunologic changes with oral immunotherapy
Safety of oral immunotherapy
Adjunctive therapies
Limitations
Future considerations/Summary
References
Mechanisms of Aeroallergen Immunotherapy: Subcutaneous Immunotherapy and Sublingual Immunotherapy
Key points
Introduction
Allergic immune response
Antigen presentation, cellular interactions, and antibody responses in allergic immune response
Immune tolerance to allergens in healthy immune response
Regulatory cells of the immune system
Mechanisms of allergen-specific immunotherapy
Innate immune responses in sublingual immunotherapy and subcutaneous immunotherapy
Influence of sublingual immunotherapy and subcutaneous immunotherapy on T-cell responses
Influence of sublingual immunotherapy and subcutaneous immunotherapy on antibody responses
Influence of sublingual immunotherapy and subcutaneous immunotherapy on effector cells
Summary
References
Mechanisms Underlying Induction of Tolerance to Foods
Key points
Immune mechanisms of oral tolerance
Evidence of oral tolerance in humans
Summary
References
Allergen Immunotherapy: Vaccine Modification
Key points
Overview
Modified allergen approaches
Cat-synthetic peptide immunoregulatory epitopes
Overlapping peptides
Summary
References
The Use of Adjuvants for Enhancing Allergen Immunotherapy Efficacy
Key points
Introduction
Immunologic mechanisms of successful allergen-specific immunotherapy
Adjuvants as means to overcome limitations of allergen-specific immunotherapy
Current adjuvants and their effects on allergen-specific immunotherapy
Summary and future outcomes
References
Baked Milk and Egg Diets for Milk and Egg Allergy Management
Key points
Introduction
Prevalence of baked milk and egg tolerance
Food processing
Predictive biomarkers
Influence on regular cow s milk and egg tolerance
Safety
Dietary guidelines
Summary
References
Biomarkers for Allergen Immunotherapy: A Panoromic View
Key points
Introduction
The ideal biomarker
Opportunities for the identification of biomarkers for allergen immunotherapy
Challenges for the identification of biomarkers for allergen immunotherapy
Diagnostic biomarkers in support of allergen immunotherapy
Predictive biomarkers of allergen immunotherapy efficacy
Follow-up biomarkers of allergen immunotherapy efficacy
Biomarkers for allergen immunotherapy safety
Future considerations
References
Allergen Immunotherapy Outcomes and Unmet Needs: A Critical Review
Key points
Introduction
Primary outcomes
Secondary outcomes
Cost-effectiveness of allergen immunotherapy
Unmet needs
Summary
Disclosure
References
Allergy Work-Up Including Component-Resolved Diagnosis: How to Make Allergen-Specific Immunotherapy More Specific
Key points
Introduction
Clinical information when allergy is suspected
Principles for the demonstration of immunoglobulin E sensitization
Allergen sources for demonstrating sensitization before allergen-specific immunotherapy
Diagnostic hurdles as a result of multisensitization to unrelated pollen species
Interpretation of sensitization tests
Challenge tests in the case of unresolved clinical relevance
Summary
References
Solving the Problem of Nonadherence to Immunotherapy
Key points
Introduction
Adherence to allergen immunotherapy
Cost versus benefit
Identifying patients likely to be nonadherent
Communication strategies to maximize adherence to allergen immunotherapy
Summary and future considerations
References
Copyright
ELSEVIER
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IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA Volume 36, Number 1
February 2016 ISSN 0889-8561, ISBN-13: 978-0-323-41694-8
Editor: Jessica McCool
Developmental Editor: Kristen Helm
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