Acute Coronary Syndromes: A Companion to Braunwald's Heart Disease E-Book , livre ebook

Acute Coronary Syndromes
A Companion to Braunwald’s Heart Disease
Second Edition

Pierre Théroux, MD
Professor of Medicine, University of Montreal, Montreal, Canada
Head Coronary Care Unit, Montreal Heart Institute, Montreal, Canada
Saunders
Front Matter

Acute Coronary Syndromes
SECOND EDITION
A Companion to Braunwald’s Heart Disease
Pierre Théroux, MD
Professor of Medicine
University of Montreal
Montreal, Canada
Head Coronary Care Unit
Montreal Heart Institute
Montreal, Canada
Copyright

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ACUTE CORONARY SYNDROMES, SECOND EDITION
ISBN: 978-1-4160-4927-2
Copyright © 2011, 2003 by Saunders, an imprint of Elsevier Inc.
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This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Acute coronary syndromes : a companion to Braunwald’s heart disease / [edited by] Pierre Theroux.—2nd ed.
p. ; cm.
Companion to: Braunwald’s heart disease / edited by Peter Libby … [et al.]. 8th ed. c2008.
Includes bibliographical references and index.
ISBN 978-1-4160-4927-2
  1.  Coronary heart disease. I.  Théroux, Pierre. II.  Braunwald’s heart disease.
[DNLM: 1.  Acute Coronary Syndrome. WG 300 A185884 2011]
RC685.C6A288 2011
616.1′23—dc22
2010021019
Executive Publisher: Natasha Andjelkovic
Editorial Assistant: Bradley McIlwain
Publishing Services Manager: Catherine Jackson
Senior Project Manager: Mary Pohlman
Design Manager: Steven Stave
Printed in United States of America
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Dedication
To
Doris
Julie, Martin, and Nelly
Marie Josée, Michel, Audrey, and Philippe
Contributors

Joseph S. Alpert, MD, Professor of Medicine Head, Department of Medicine University of Arizona Health Science Center Tucson, Arizona

Jeffrey L. Anderson, MD, FACC, FAHA, Intermountain Healthcare Hospitals Salt Lake City, Utah

Elliott M. Antman, MD, Brigham and Women’s Hospital, Cardiovascular Division TIMI Study Group Boston, Massachusetts

Nipun Arora, MD, University of Missouri-Columbia Columbia, Missouri

Jean-Pierre Bassand, MD, Cardiology Department University Hospital Besançon Besançon, France

Shannon M. Bates, MD, CM, Department of Medicine McMaster University Henderson Research Centre Hamilton, Ontario, Canada

Richard C. Becker, MD, Divisions of Cardiology and Hematology Duke University Medical Center Cardiovascular Thrombosis Center Duke Clinical Research Institute Durham, North Carolina

Jacob Fog Bentzon, MD, PhD, Atherosclerosis Research Unit Department of Cardiology Aarhus University Hospital, Skejby, Brendstrupgaardsvej Aarhus, Denmark

Deepak L. Bhatt, MD, Associate Director Cleveland Clinic Cardiovascular Coordinating Center Department of Cardiovascular Medicine Cleveland Clinic Cleveland, Ohio

Olivier Blanc-Brude, PhD, Cardiovascular Research Center Inserm-Lariboisière Hôpital Lariboisière Paris, France

Eugene Braunwald, MD, Brigham and Women’s Hospital, Cardiovascular Division TIMI Study Group Department of Medicine Harvard Medical School Boston, Massachusetts

Ralph G. Brindis, MD, MPH, Oakland Medical Center Oakland, California

Kenneth A. Brown, MD, Professor of Medicine and Cardiology Professor of Radiology University of Vermont College of Medicine Burlington, Vermont

Christopher P. Cannon, MD, Brigham and Women’s Hospital TIMI Study Group Boston, Massachusetts

Bernard R. Chaitman, MD, FACC, Department of Medicine Division of Cardiology Saint Louis University School of Medicine St. Louis, Missouri

Wai-Hong Chen, MBBS, Division of Cardiology, Department of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong, China

Clara Kayei Chow, MBBS, FRACP, PhD, Director, Population Health Research Institute Hamilton General Hospital Hamilton, Ontario, Canada

Kuang-Yuh Chyu, MD, PhD, Division of Cardiology and Atherosclerosis Research Center Cedars-Sinai Heart Institute Los Angeles, California

Patrick Commerford, MBChB, FCP(SA), Professor of Cardiology Department of Medicine University of Cape Town Cape Town, South Africa

Simon de Denus, BPharm, MSc, Assistant Professor, Faculty of Pharmacy Université de Montréal, Department of Pharmacy Montreal Heart Institute Montreal, Quebec, Canada

Pim J. de Feyter, MD, PhD, FACC, Erasmus MC Rotterdam, The Netherlands

Michel de Lorgeril, MD, Faculty of Medicine Domaine de la Merci University of Grenoble La Tronche, France

Leonardo De Luca, MD, PhD, Department of Cardiovascular Sciences Laboratory of Interventional Cardiology European Hospital Rome, Italy

Ariel Diaz, MD, MSc, Department of Medicine Université de Montreal Montreal Heart Institute Montreal, Quebec, Canada

Anique Ducharme, MD, MSc, Department of Medicine Université de Montreal Montreal Heart Institute Montreal, Quebec, Canada

Erling Falk, MD, PhD, Atherosclerosis Research Unit Department of Cardiology Aarhus University Hospital, Skejby, Brendstrupgaardsvej Aarhus, Denmark

Richard Gallo, MD, FRCPC, FACC, Interventional Cardiologist Montreal Heart Institute; Associate Professor of Medicine University of Montreal Montreal, Quebec, Canada

Anselm K. Gitt, MD, Institut fuer Herzinfarktforschung Ludwigshafen an der Universitaet Heidelberg Heidelberg, Germany

Christopher B. Granger, MD, Duke Clinical Research Institute and the Division of Cardiology Department of Medicine Duke University Medical Center Durham, North Carolina

Paul Gurbel, MD, Sinai Center for Thrombosis Research Sinai Hospital of Baltimore Baltimore, Maryland

Christian W. Hamm, MD, FACC, Medical Director Kerckhoff Heart Center Bad Nauheim, Germany

David Hasdai, MD, Intensive Cardiac Care Unit Rabin Medical Center Petah Tikva, Israel

Allan S. Jaffe, MD, Professor of Medicine Mayo Clinic Rochester, Minnesota

E. Marc Jolicoeur, MD, MSc, Assistant Profesor of Medicine Université de Montréal Montreal, Quebec, Canada

Martin Juneau, MD, Co-president, Cardiologist and Manager of Prevention Montreal Heart Institute Montreal, Quebec, Canada

Jason N. Katz, MD, Duke Clinical Research Institute and the Division of Cardiology Department of Medicine Duke University Medical Center Durham, North Carolina

Catherine Labbé, MSc, Université de Montréal Montreal Heart Institute Montreal, Quebec, Canada

Jennifer Lash, MD, Department of Medicine Division of Cardiology Saint Louis University School of Medicine St. Louis, Missouri

Peter Libby, MD, Brigham and Women’s Hospital Cardiovascular Division Boston, Massachusetts

Jens Lohrmann, MD, Division of Cardiology Universitäts of Freiburg Freiburg, Germany

Telly A. Meadows, MD, Department of Cardiovascular Medicine Cleveland Clinic Cleveland, Ohio

Jessica L. Mega, MD, MPH, Brigham and Women’s Hospital, Cardiovascular Division TIMI Study Group Boston, Massachusetts

Shamir R. Mehta, MD, MSc, FRCPC, Director, Interventional Cardiology and Acute Coronary Syndrome Research Program Population Health Research Institutes Hamilton Health Sciences McMaster Clinic Hamilton, Ontario, Canada

L. Kristin Newby, MD, MHS, Duke Clinical Re