The role of PGRP proteins in innate immunity pathways in the malaria vector Anopheles gambiae [Elektronische Ressource] / presented by Stephan Meister

244

pages

English

Documents

2006

Écrit par
Stephan Strogoff

Publié par
ruprecht-karls-universitat_heidelberg

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244

pages

English

Documents

2006

Lire un extrait

Obtenez un accès à la bibliothèque pour le consulter en ligne En savoir plus

Publié par

ruprecht-karls-universitat_heidelberg

Publié le

01 janvier 2006

Nombre de lectures

Langue

English

Poids de l'ouvrage

10 Mo

SUMMARY Innate immunity is the first line of defense against invading microorganisms and provides clues to adaptive immunity for the development of memory for subsequent infections. Insects, similar to other invertebrates, do not have adaptive immunity and thus rely on their innate immune system to combat infections. We have analyzed the role of the peptidoglycan (PGN) receptor protein (PGRP) family and other components of innate immune signaling pathways in the immune defense of the mosquito Anopheles gambiae, the main vector of human malaria in sub-Saharan Africa. The PGRP gene family consists of seven genes with ten PGRP domains. We have shown that from all PGRP genes only PGRPLC has a role in the resistance to bacterial infections of both Gram types. In our experiments we have used the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli. The PGRPLC gene encodes at least three isoforms that derive from infection-driven alternative splicing of a pool of immature transcripts. Each isoform contains a different PGRP domain, encoded by three exons that all contribute equally to the PGN binding pocket. Structural modeling of the PGRPLC isoforms revealed a potential for all isoforms to bind both types of PGN, the Lys-type, which is mostly found in Gram-positive bacteria and the DAP-type, mostly found in Gram-negative bacteria.

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Publié par

ruprecht-karls-universitat_heidelberg

Publié le

01 janvier 2006

Langue

English

Poids de l'ouvrage

10 Mo

Biologie

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