Comment et pourquoi Im'Prouve ALC réduit le TB

HOW AND WHY DOES A CALCIUM SALT OF C18 :2 Trans-10, Cis-12 ISOMER DECREASE MILK FAT CONTENT? XERIS S.A. – 5 Place des Vosges – 56 860 SENE 1 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1 SUMMARY Page I- ORIGIN OF MILK FAT CONTENT…………………..………………….3 II- WHY DOES IM’PROUVE ALC REDUCE MILK FAT CONTENT?…..4 III- IS IM’PROUVE ALC EFFICIENT WHATEVER THE RACE AND THE DIET ARE ?……………………..5 IV- WHY DOES IM’PROUVE ALC INCREASE MILK PRODUCTION AND MILK PROTEIN CONTENT?……………5 V- WHEN CAN YOU USE IM’PROUVE ALC ?…………………………..7 VI- HOW LONG TO NOTE IM’PROUVE ALC EFFECTS?………………8 XERIS S.A. – 5 Place des Vosges – 56 860 SENE 2 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1  HOW AND WHY DOES A CALCIUM SALT OF C18 :2 Trans- 10, Cis-12 ISOMER DECREASE MILK FAT CONTENT? I- ORIGIN OF MILK FAT CONTENT Milk fat content has two origins: 1- The first origin 50% in moles and 50% in weight of fatty acids secreted by udder are about mammary absorption of long chain of fatty acids (fatty acids composed of 12 to 22 atoms of carbon) from plasma from lipoproteins of intestinal absorption of feed lipids or of ruminal synthesis origins, from fatty acids non esterified (AGNE) of corporeal lipids mobilization origin. 2- The second origin 50% in moles and 50% in weight of fatty acids secreted are about intramammary synthesis (fatty acids of 4 to 16 atoms of carbon = small chain of fatty acids). This synthesis is realized from acetate of ruminal origin or beta-hydroxybutyrate of butyrate metabolism origin from ruminal epithelium. NB : An enzyme called – delta-9 desaturase – produced from intestine and udder is active on long and medium chain of fatty acids. This enzyme has no effect on small chain of fatty acids. Delta-9 desaturase is essential for desaturation of long chain of fatty acids. XERIS S.A. – 5 Place des Vosges – 56 860 SENE 3 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1 For example, delta-9 desaturase Stearic acid Oleic acid C18 :0 C18 :1 delta-9 desaturase Vaccenic acid Rumenic acid C18 :1 Trans-11 C18 :2 Cis-9, Trans-11 Conjugated Linoleic Acid (CLA) from milk fat content II- WHY DOES IM’PROUVE ALC REDUCE MILK FAT CONTENT? Im’Prouve ALC is a calcium salt (By-pass) that contains two isomers. The isomer Trans-10, Cis-12 C18 :2 inhibits fatty acids synthesis from udder. Udder produces 50% of milk fat. So we can’t reduce milk fat content more than 50% with Im’Prouve ALC. Inhibition of fatty acids synthesis is reversible. Im’Prouve ALC supplementation permits to decreases milk fat content in 15 days. This decreasing endures about 40 days. You have got maximum dose effect of Im’Prouve ALC at 40 days of supplementation. If milk fat content decreasing is too high you can reduce Im’Prouve ALC supplementation. You need about 7 days after non Im’Prouve ALC supplementation to have again initial milk fat content. With 20 g of Im’Prouve ALC, it is 6 g of Trans-10, Cis-12 isomer per day 6 g of Cis-9, Trans-11 isomer per day With 10 g of Im3 3 g of Cis-9, Trans-11 isomer per day XERIS S.A. – 5 Place des Vosges – 56 860 SENE 4 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1 III- IS IM’PROUVE ALC EFFICIENT WHATEVER THE RACE AN THE DIET ARE? Im’Prouve ALC is efficient whatever the race and the diet because udder has the same metabolism. When diet is rich of acetate (hay) Im’Prouve ALC effect will be more interesting. IV- WHY DOES IM’PROUVE ALC INCREASE MILK PRODUCTION AND MILK PROTEIN CONTENT? “UFL” (net energy expressed in France) per litre of milk is about 0,44 UFL. This value is according to fats level: UFL / kg = 0,43 (0,4 + 0,15 x milk fat level*) *Milk fat level, % of fats Milk fat level 3,0% 3,5% 4,0% 4,5% 5,0% Need UFL / kg of 0,37 0,40 0,43 0,47 0,50 milk A cow that produces 25 kg of milk at 4,5% milk fat level needs 25 kg x 0,47 UFL / kg = 11,75 UFL / day, 25 kg of milk at 3,8% milk fat level needs 25 kg x 0,42 UFL / kg = 10,50 UFL / day With 20 g per day of Im’Prouve ALC this cow at 4,5% milk fat level reduces its energetic need from 11,75 UFL per day to 10,50 UFL per day. It is about a decreasing of 1,25 UFL per day. XERIS S.A. – 5 Place des Vosges – 56 860 SENE 5 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1 UFL released are used for milk production and for milk protein content production. Milk production realized from UFL released is about: 1,25 UFL : 0,42 UFL per kg = + 3 kg of milk per day So with Im’Prouve ALC, milk production increases of 15%. Milk production UFL supplied per day Without Im’Prouve ALC 25 kg / day Same With 20 g / day of Im’Prouve ALC 28 kg / day Samee With 20 g / day of Im’Prouve ALC + 3 kg / day Economy of + 12% 1,25 UFL per day Economy value of Im’Prouve ALC per kg is about 62,50 UFL. XERIS S.A. – 5 Place des Vosges – 56 860 SENE 6 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1 V- WHEN CAN YOU USE IM’PROUVE ALC ? 1- « Spot » action: if your target is to reduce immediatly milk fat content for all animals 20 g per day of Im’Prouve ALC supplementation. You need about 40 days to obtain maximum dose effect, Supplementation for all cows is advised, If you want to increase milk fat content, it is important to reduce supplementation by 50% (10 g per day of Im’Prouve ALC). 2- Long term action : if your target is to improve milk production 20 g per day of Im’Prouve ALC supplementation in winter, 20 g per day of Im’Prouve ALC supplementation in spring during grazing period, Im’Prouve ALC supplementation from calving period to 200 days in lactation period. XERIS S.A. – 5 Place des Vosges – 56 860 SENE 7 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1 VI- HOW LONG TO NOTE IM’PROUVE ALC EFFECTS? 20 g of Im’Prouve ALC / cow / day supplementation Day 0 Day 15 Day 30 Day 40 15 days During the first 15 days, no After 15 days of After 30 days, you At Day 40, there is the effects on milk fat content and supplementation, milk can note a good maximum dose effect (20 g / milk production. fat content decreases lactation persistence cow / day) on milk fat content. of 4 – 5 points. This (energetic economy - 15% according to initial milk decreasing endures 40 effect). fat content. days after initial days of supplementation. This decreasing will be constant for this supplementation. You can also note milk production and milk protein content increasing. Daily milk production increasing is about 3 kg per cow. Milk protein content improvement is noted for animals in lactation period inferior to 150 days of lactation. If milk fat content decreasing is too important, you can reduce Im’Prouve ALC dose by 50%: 10 g of ALC / cow / day. NB : When you stop Im’Prouve ALC supplementation, you need about 7 days to obtain initial value of milk fat content. XERIS S.A. – 5 Place des Vosges – 56 860 SENE 8 Tél. 02 97 68 81 22 – Fax 02 97 68 86 14 www.xeris-online.com Version 1