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2005
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217
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2005
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Publié par
Publié le
01 janvier 2005
Nombre de lectures
23
Langue
Deutsch
Poids de l'ouvrage
2 Mo
Publié par
Publié le
01 janvier 2005
Nombre de lectures
23
Langue
Deutsch
Poids de l'ouvrage
2 Mo
SYNTHESE VON CYCLISCHEN
DISACCHARIDEN
DURCH
INTRAMOLEKULARE GLYCOSYLIERUNG
Dissertation
der Fakultät Chemie-Pharmazie
der Eberhard-Karl- Universität Tübingen
zur Erlangung des Grades eines Doktors
der Naturwissenschaftten
2005
vorgelegt von
Patrick Claude
Tag der Mündlichern Prüfung: Juni 3 2005
Dekan : Prof. Dr.rer.nat. S. Laufer
1. Berichterstatter: Prof. Dr. rer. nat. T. Ziegler
2. Berichterstatter: Prof. Dr. rer. nat. M. Maier
Aknowledgements
My scientific research work has been carried out partially at the University of Cologne
and, University of Tübingen under the supervision of Professor Dr. Thomas Ziegler, to
whom I would like to express my warmest gratitude for communicating to me his
fruitful instructions and knowledge in exploring the vast and important specialty of
carbohydrate chemistry that allowed me to grow as an organic chemist.
I express my best thanks to
To the members of the jury Professor Dr. Thomas Ziegler, Professor Dr. Martin Maier,
Professor Dr. Lars Wesemann, Professor Dr. Stefan Laufer, and Professor Dr. Ulrich Nagel for
taking their precious time to read and appreciate my written thesis.
Dr. Subramanian for his disponibility and very fruitful scientific and administrative advices.
Dr. H Schmickler at the University of Cologne for the numerous measurements of one and
two dimensional-NMR spectroscopies, and also for his very fruiful advices concerning the
NMR analysis.
Mrs. Hoven at the University of Cologne for the NMR –measurements.
Mr. Paul Schuler from the University of Tübingen for measuring the NMR –spectrums from
the 600 MHz instrument, and for taking his time to install the X-Win-NMR 3.0 program for
our working group.
Mrs. NGuyen for the one and two dimensional spectrum measurements on the 400Mhz.
Dr. H. Müller and Mr.G. Nicholson for the High Resolution Mass Spectroscopy
measurements.
Dr. Christian Lehman from the University of Lausanne who graciously accepted our
invitation by taking his precious time to hold an important seminar about Molecular
Modelling to our institute and his important lecture to our working group.
I thank him very much for the molecular modelling measurements of my compounds
and his instructing advices.
Dr. Gregor Lemanski for his good scientific advices.
To all the collegues from the group of Pr. Dr. Thomas Ziegler for the creative atmosphere
and research discussions.
The beauty of scientific research is the endless learning
process and adventure, that leaving us so many
universes to discover which requires
on our part , regardless our level
Wisdom and modesty
Dedication
I dedicate my thesis to my wonderful parents who endlessly manifested toward me
their deepest affection and support throughout all the all the delicate periods of my life.
I am so lucky to have you as parents, and I deeply love you
To the rest of my family who showed me much mental support during this crucial period of my
dissertation, and to the good friends of the family as well as mines who manifested the same
support.
I thank you very much, you all have my great considerations.
TABLE OF CONTENTS
1. Abbreviations
2. Introduction............................................................................................................ 1-8
3. Chapter I.
Leaving Group Bases Intramolecular Glycosylation................................................10- 29
4. Chapter II.
Linkage of the Accepting Atom via Bifunctional Group. .......................................30 - 62
5. Chapter III.
Spacer- Mediated Linkage via Nonreacting Centers..............................................63 - 115
6. Chapter IV.
Intramolecular Glycosylation via Succinylamide alkyl Spacer and
Molecular Modelling........................................................................................... 116 - 161
7. Experimental Part.
Instrumentation, reagents and material. ................................................................ 162 - 163
Nomencature of synthesized compounds. ............................................................. 164 - 166
Experimental Procedures. ..................................................................................... 167 - 187
8. Zuzammenfassung (Summary). ..........................................................................188 -193
9. Bibliography. .................................................................................................... 194 - 198
Abbreviations
Ac Acetyl
Ac O Acetic anhydride 2
AgOTf Silver trifluoromethanesulphonate
Bn Benzyl
BnBr Benzyl bromide
Bz Benzoyl
BzCl Benzoyl chloride
BF Et O Boron trifluoride etherate 3. 2
Bu SnO Dibutyl tin oxide 2