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AP U.S. History Name________________________ Chapter 14 Forging the National Economy, 1790-1860 A. True or False Where the statement is true, mark T. Where it is false, mark F, and correct it in the space immediately below. ___ 1. American frontier life was often grim and plagued by poverty and illness ___ 2.

major highway
businesses with large capital investments
cotton production
cotton-spinning factory
common source of early factory labor
patent system
labor unions
economic effect
women

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Super Oxidized Solutions (SOS)
From the Basic Science to the Bedside
Andrés A Gutiérrez MD PhD
Oculus Innovative Sciences
Petaluma, California Use of Antimicrobials in Wound Care
Oral-Parenteral Antibiotics
• First line therapy in wound infection / colonization
• Emergence of resistant bacteria
• Side effects and increased costs of treatment
Topical Antimicrobials
• Biocides could be useful but are toxic
• Poor quality of trials & small sample size
• SOS therapy ?Early Super Oxidized Solutions
• Produced by the electrolysis of water and NaCl
• Acidic or alkaline pH
• High Chlorine content (> 500 ppm)
• Potent anti-infective agents w/ clinical uses
• Unstable - Shelf life of days or hours
• Irritation and sensitization
Tanaka. JHI, 1996
Inoue, Artif Org, 1997Challenge for Oculus
Neutral pH Solution
Low chlorine content
Preserves biocidal activity
Non irritation –sensitization
S T A B L EpH neutral-pH neutral-Super Oxidized Super Oxidized Solutions
®Microcyn Technology
Chemical Reactions
®• Microcyn Technology utilizes a unique
multi chamber electrolysis cell
O , O , and others2 3
• Oxidized Water 99.9 %
H O2
• Reactive oxychlorine species 0.1 %
• FAC ≤ 80 ppm + H O2
HOCl + HClCl2 • pH 7.2-7.8
+ NaOH
- • Stable for over 1 year2Cl
NaOCl
-
Anode eResearch & Development
Phase 3
(2) 2008
Phase 2
(1)
Pilot Studies
US 3, EU 2, India 1
OUS Clinicals
(21)
1999 2004
Preclinical
2002pH neutral-pH neutral-Super Oxidized Super Oxidized Solutions
• Microcyn Technology Core
Technology
TM• Dermacyn Wound Care Medical
(Oxum, Microcyn60) Device
• OIS-1080 DrugpH Neutral pH Neutral – – Super Oxidized Solution
Preclinical Background
Biocide
(planktonic bacteria & biofilms)
Healing Safety
Anti-Inflammatory Vasodilation
AntihistaminePreclinical Background
Publications
• Yahagi N Artif Org 2000 Healing clean wounds
• Landa C J Hosp Infect 2005 Antimicrobial
• Various Wounds 2006 Overview
• Medina J Int Immun 2007 Anti-histamine,TNF block
• González D Int Wound J 2007 Fibroblast
• Le Duc Q Br J Dermatol 2007 Skin grafts & substitutesClinical Studies - Summary
• 21 physician clinical studies in US, Europe, India and Mexico
TM • > 700 patients on Microcyn
• No reported significant adverse events
• Significant ↓ in infection & bacterial count
• Other benefits in some clinical studies:
• ↓ healing time and ↓ hospital stay
• ↓ use of systemic antibiotics
• ↓ major amputations/re-interventions
• Significant cost savings