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- cours magistral - matière potentielle : hispalensis
- expression écrite
- postdoctoral research associate
- approach to nuclear matter at finite temperature
- sep 2004 jan
- research experience sep 2002 feb 2007 phd
- nuclear matter
- effective interaction dependence
- entropy of a correlated system of nucleons
- aug 2009 aug
- physics
Genetics 418 Lecture 1
1/8/12
1) Chromosomes
a) Nuclear
2n = 46
Genetics 418
Lecture 1 46,XX
Human genome organization
46,XY
Wikipedia:Chromosome
2 1
c) Summary
b) Mitochondrial
Feature Nuclear Mit.
genome genome
Size 3100 Mb 16.6 kb
Different DNAs 24 1
Protein encoding genes ~21 000 13
RNA encoding genes > 6000 24
Introns yes no
Repetitive DNA yes no
3 4
3) Transposable elements
2) High-copy number tandemly repeated DNA
a) Types
Class Array size Location
Satellite DNA > 100 kb centromeres
Minisatellite DNA 0.1 - 20 kb telomeres
Microsatellites < 100 bp dispersed
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1Genetics 418 Lecture 1
1/8/12
b) Consume resources
LINEs
Long Interspersed Nuclear Elements Mobilization requires new RNAs and new Proteins
6 - 8 kb
e.g. L1 Continued existence requires DNA replication
SINEs
Short Interspersed Nuclear Elements
100 - 300 bp
e.g. Alu
7 8
c) Cause mutations Providing sites for
inappropriate meiotic cross overs
New insertions can disrupt genes
9 10
d) Facilitate evolution by changing gene expression Alter transcription termination
Alter pre-mRNA splicing
Cordaux and Batzer (2009) The impact of retrotransposons on human
genome evolution. Nature Reviews Genetics 10:691
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2Genetics 418 Lecture 1
1/8/12
Alter the local epigenetic environment Alter transcription factor recruitment to
regulatory regions
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